Modular synthesis of all-substituted furans through oxidative carbonylation of cyclopropenes with tandem metal relay catalysis.
نویسندگان
چکیده
A modular synthesis of tetrasubstituted furan carboxylates using a tandem cycloisomerization/oxidative carbonylation sequence of cyclopropenes has been successfully developed. The Tandem Metal Relay Catalysis (TMRC) pathway accounted for the high efficiency of this transformation.
منابع مشابه
Dimerization of cyclopropenes to bifurans using tandem metal relay catalysis.
An efficient synthesis of bifurans via dimerization of cyclopropenes has been successfully developed using a copper-promoted cycloisomerization and palladium-catalyzed dimerization cascade. These novel bifuran structures possess interesting optoelectronic properties.
متن کاملHighly selective synthesis of tetra-substituted furans and cyclopropenes: copper(I)-catalyzed formal cycloadditions of internal aryl alkynes and diazoacetates.
A convenient Cu(I)-catalyzed cycloaddition of electron rich internal aryl alkynes and diazoacetates was discovered for the chemoselective and regioselective synthesis of tetra-substituted furans and cyclopropenes in moderate isolated yields (18-67%), and alkyne conversion (29-73%).
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Tandem reactions and consecutive catalysis (or relay catalysis) have been receiving considerable attention in organic synthesis due to their abilities of constructing multiple new chemical bonds to build complex chiral molecules in a single operation. Transition-metal-catalyzed asymmetric hydrogenation is one of the most widely used and reliable catalytic methods for preparation of chiral molec...
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 11 37 شماره
صفحات -
تاریخ انتشار 2013